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以明生物Immune-Onc将参加11月3日下午
临床公司路演专场，汇报时间20分钟。
以明生物是一家处于临床研发阶段的生物制药公司，专注于癌症免疫治疗，致力于为癌症患者研发全新的髓系细胞免疫检查点抑制剂。公司的目标是通过转化对髓系细胞生物学和免疫抑制性受体独到的科学见解，发现并开发可以在肿瘤微环境中解除免疫抑制的首创生物新药。
公司围绕髓系细胞免疫检查点——白细胞免疫球蛋白样受体亚家族B（LILRB），利用生物学平台的协同效应，已打造出多条极具潜力的产品管线。其中包括两款处于临床开发阶段的全球首创新药：针对实体瘤、靶向LILRB2（又称ILT4）的全新抑制性抗体IO-108于2021年进入临床；靶向LILRB4（又称ILT3）的抑制性抗体IO-202于2020年进入临床，现已开展针对血液瘤和实体瘤的I期临床试验。美国食品药品监督管理局（FDA）授予IO-202用于急性髓系白血病的孤儿药资格和快速通道资格认定。此外，公司产品管线还包括一款靶向LAIR1的首创抑制性抗体新药IO-106和一款靶向LILRB4的首创双抗新药IO-312，以及多个未公开的针对实体瘤和恶性血液瘤的项目。
以明生物已与包括百济神州和再生元在内的行业领先的生物制药公司建立合作，支持其IO-108和IO-202项目的全球产品开发计划。公司也获得了美国国立卫生研究院（NIH）旗下的国家癌症研究所（NCI）和加州再生医学研究所（CIRM）的研究资助，以及白血病和淋巴瘤学会（LLS）治疗加速计划（ TAP®）的战略投资。以明生物总部位于美国加州帕洛阿托市，在中国杭州和上海设有运营，现已组建了一支在药物开发领域经验丰富，具有全球顶尖生物科技公司深厚资历的多元化团队。
Immune-Onc Therapeutics Inc. (“Immune-Onc”) is a private, clinical-stage cancer immunotherapy company dedicated to the discovery and development of novel myeloid checkpoint inhibitors for cancer patients. The company aims to translate unique scientific insights in myeloid cell biology and immune inhibitory receptors to discover and develop first-in-class biotherapeutics that inhibit immune suppression in the tumor microenvironment.
Immune-Onc has a differentiated pipeline with a current focus on targeting the Leukocyte Immunoglobulin-Like Receptor subfamily B (LILRB) of myeloid checkpoints. Immune-Onc’s focused platform approach has led to the development of several promising therapeutics across various stages of development. Those include IO-108, an antagonist antibody targeting LILRB2 (also known as ILT4), in Phase 1 clinical development for solid tumors and IO-202, a first-in-class antagonist antibody targeting LILRB4 (also known as ILT3), in Phase 1 clinical development for the treatment of acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML), and solid tumors. Additional assets in Immune-Onc’s pipeline include IO-106 (first-in-class antagonist antibody targeting LAIR1), IO-312 (bi-specific antibody targeting LILRB4), and multiple undisclosed programs for solid tumors and hematologic malignancies.
Immune-Onc has established agreements with leading biopharmaceutical companies, including BeiGene and Regeneron, to support its global product development plans for IO-108 and IO-202. It has received research grants from the National Cancer Institute (NCI) of the National Institutes of Health (NIH) and the California Institute for Regenerative Medicine (CIRM) and investment from The Leukemia & Lymphoma Society Therapy Acceleration Program® (LLS TAP®). Headquartered in Palo Alto, California, Immune-Onc has assembled a diverse team with deep expertise in drug development and proven track records of success at leading biopharmaceutical companies.
