减重30斤！礼来减肥新药第二个3期临床试验成功，有望年底获批上市

 收藏

关键词：新药获批成功减肥期临床临床药礼来上市

资讯来源：药时代

发布时间： 2023-04-30

</section><section style="text-align: center;margin-left: 8px;margin-right: 8px;"><br/></section><p arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0.5em;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><img arial="" auto="" center="" class="rich_pages wxw-img" data-backh="258" data-backw="578" data-ratio="0.44722222222222224" data-s="300,640" data-src="https://mmbiz.qpic.cn/mmbiz_png/HO0Z9pUcnJkNq0Pdq7YHhcFmDAZQiaibyZb1IzSaBcrT4AhJqCzicgah79iaLbvhgNQMt49wD28GN0Cp8SkiaMfT5MQ/640?wx_fmt=png&wxfrom=5&wx_lazy=1&wx_co=1" data-type="png" data-w="1080" gb="" helvetica="" neue="" sans="" sans-serif="" sc="" style="outline: 0px;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""/></p><p arial="" center="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0em;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><img class="rich_pages wxw-img" data-backh="28" data-backw="562" data-cropselx1="0" data-cropselx2="562" data-cropsely1="0" data-cropsely2="28" data-galleryid="" data-ratio="0.049074074074074076" data-s="300,640" data-src="https://mmbiz.qpic.cn/mmbiz_jpg/HO0Z9pUcnJnv9o4yFwPS0ic94piabrXscNDT0D5a2mHxX5DH0hwOIwYmHnBQcKsN4Zaic6FSfPDLicvSNDXDlAFLiaw/640?wx_fmt=jpeg" data-type="jpeg" data-w="1080" style="outline: 0px;width: 100%;visibility: visible !important;height: auto;"/></p><p arial="" gb="" helvetica="" left="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0em;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="outline: 0px;color: rgb(136, 136, 136);font-size: 12px;letter-spacing: normal;visibility: visible;">撰文丨王聪</span></p><p arial="" gb="" helvetica="" left="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0em;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="outline: 0px;font-size: 12px;color: rgb(136, 136, 136);letter-spacing: normal;visibility: visible;">编辑丨王多鱼</span></p><p arial="" gb="" helvetica="" left="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0em;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="outline: 0px;font-size: 12px;color: rgb(136, 136, 136);letter-spacing: normal;visibility: visible;">排版丨水成文</span></p><p arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><br/></p><p arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="outline: 0px;font-size: 15px;visibility: visible;letter-spacing: normal;">2023年4月27日，<strong>礼来公司</strong></span><span style="outline: 0px;font-size: 15px;visibility: visible;letter-spacing: normal;color: rgb(136, 136, 136);">（Eli Lilly）</span><span style="outline: 0px;font-size: 15px;visibility: visible;letter-spacing: normal;">宣布其热门减肥候选药物</span><span style="outline: 0px;font-size: 15px;visibility: visible;letter-spacing: normal;color: rgb(217, 33, 66);"><strong><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">替尔泊肽</span></strong></span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（Tirzepatide）</span><span style="outline: 0px;font-size: 15px;visibility: visible;letter-spacing: normal;">取得</span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">了第二次关键临床试验成功——再次取得了令人印象深刻的结果。</span></p><p arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><br/></p><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="outline: 0px;font-size: 15px;visibility: visible;letter-spacing: normal;">礼来表示，在这项名为<span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">SURMOUNT-2的3期临床试验中，<span arial="" gb="" helvetica="" neue="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">替尔泊肽</span><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（Tirzepatide）</span></span></span><strong><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">帮助肥胖或超重的糖尿病患者减掉了15.7%的体重</span></strong><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">（15.6公斤）</span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">，且在各种减肥和代谢测量方面的表现明显优于安慰剂，SURMOUNT-2研究达到了两个共同主要终点和所有关键次要终点。</span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei=""><br/></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">而在一年前的<span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">2022年4月28日，礼来公司<span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">公布了</span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><strong><span style="outline: 0px;visibility: visible;background-color: rgb(255, 255, 255);">替尔泊肽</span></strong></span><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（Tirzepatide）</span></span>在非糖尿病的肥胖患者中的减肥效果，在名为<span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">SURMOUNT-1的3期临床试验中，<strong>参与者<span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">平均体重减轻最高可达22.5%</span></strong></span></span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">（24公斤）</span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">。这是迄今为止通过药物减肥的最佳效果，超过了诺和诺德开发的<strong>司美格鲁肽</strong></span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">（Semaglutide）</span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">的3期临床减肥效果。</span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><br/></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">有了这两项3期临床试验结果，礼来公司表示，将在未来几周内向FDA提交<span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><strong><span style="outline: 0px;visibility: visible;background-color: rgb(255, 255, 255);">替尔泊肽</span></strong></span><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（Tirzepatide</span></span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">）</span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">作为减肥药物用于肥胖或超重的成年人的滚动申请，</span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">预计最早将于2023年底获得FDA批准。</span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="font-size: 15px;letter-spacing: normal;"><br/></span></section><section arial="" center="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><strong><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">肥胖每年导致500万人死亡？</span></strong></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="color: rgb(42, 43, 46);font-family: PingFangSC-Regular;font-size: 26px;letter-spacing: normal;text-align: start;white-space: pre-wrap;caret-color: rgb(42, 43, 46);background-color: rgb(255, 255, 255);"><br/></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="font-size: 15px;letter-spacing: normal;"><img arial="" auto="" class="rich_pages wxw-img" data-backh="365" data-backw="578" data-cropselx1="0" data-cropselx2="578" data-cropsely1="0" data-cropsely2="252" data-ratio="0.6314814814814815" data-s="300,640" data-src="https://mmbiz.qpic.cn/mmbiz_jpg/HO0Z9pUcnJkvRKFicGqaNpLHvxAOdVjxhX56eXDPichoCZ3hL4BlF9B7KyRXTZ2PicD5y9o0KkWhIpCMcpDAtVmvg/640?wx_fmt=jpeg&wxfrom=5&wx_lazy=1&wx_co=1" data-type="jpeg" data-w="1080" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);white-space: normal;background-color: rgb(255, 255, 255);outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""/></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><br/></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">据世界卫生组织</span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（WHO）</span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">统计，</span><strong arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">全球有近20亿人超重或肥胖</strong><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">，<span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">实际上，肥胖不仅会导致生活不便、运动能力下降，还会增加糖尿病等代谢性疾病和心脑血管疾病风险。许多研究表明，肥胖与十多种癌症的发病风险增加和预后及生存率降低有关。</span></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei=""><br/></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">2023年3月，</span><span style="font-size: 15px;letter-spacing: normal;">新加坡国立大学联合美国和中国研究人员在</span><strong><span style="font-size: 15px;letter-spacing: normal;"> Cell Metabolism</span></strong><span style="font-size: 15px;letter-spacing: normal;"> 期刊发表了一项题为：</span><span style="font-size: 15px;letter-spacing: normal;color: rgb(64, 118, 0);">The global burden of metabolic disease: Data from 2000 to 2019 </span><span style="font-size: 15px;letter-spacing: normal;">的研究。</span><span style="outline: 0px;visibility: visible;font-size: 15px;letter-spacing: normal;">该研究分析了全球疾病负担</span><span style="outline: 0px;visibility: visible;font-size: 15px;letter-spacing: normal;color: rgb(136, 136, 136);">（Global Burden of Disease，GBD）</span><span style="outline: 0px;visibility: visible;font-size: 15px;letter-spacing: normal;">报告中2000-2019年这20年里的代谢疾病数据。</span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="outline: 0px;visibility: visible;font-size: 15px;letter-spacing: normal;"><br/></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="outline: 0px;visibility: visible;font-size: 15px;letter-spacing: normal;">分析结果显示，在过去20年里，代谢性疾病的发病率不断上升，对全球健康构成了巨大负担，其中肥胖相关死亡人数最多，</span><span style="outline: 0px;visibility: visible;font-size: 15px;letter-spacing: normal;color: rgb(217, 33, 66);">在2019年，全世界肥胖相关死亡人数高达500万人。</span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><br/></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><img class="rich_pages wxw-img" data-galleryid="" data-ratio="0.3851851851851852" data-s="300,640" data-src="https://mmbiz.qpic.cn/mmbiz_png/HO0Z9pUcnJlYNItqtz8FK1dpLsTOx9zB2DmjHs5RIDccy2v5CKclqEdhOZrdU3L2ibTzT0icC0FY8vL13YvVia1EA/640?wx_fmt=png&wxfrom=5&wx_lazy=1&wx_co=1" data-type="png" data-w="1080" style="outline: 0px;text-align: center;box-shadow: rgb(210, 210, 210) 0em 0em 0.5em 0px;width: 677px !important;visibility: visible !important;"/></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><br/></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="letter-spacing: normal;"><span style="outline: 0px;font-size: 15px;visibility: visible;">基于健康或美的考虑，越来</span><span style="font-size: 15px;">越多的人开始减肥。最有效的减肥方式无异是运动＋节食，但绝大多数减肥者难以坚持，因此许多人希望能够通过药物达到快速减肥的目的。</span></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="letter-spacing: normal;"><span style="font-size: 15px;"><br/></span></span></section><section arial="" center="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="font-size: 15px;letter-spacing: normal;color: rgb(2, 30, 170);"><strong arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span style="font-size: 15px;letter-spacing: normal;color: rgb(2, 30, 170);outline: 0px;visibility: visible;">替尔泊肽的减肥原理</span></strong></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="outline: 0px;font-size: 15px;letter-spacing: normal;"><br/></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="outline: 0px;font-size: 15px;letter-spacing: normal;"><strong arial="" gb="" helvetica="" neue="" normal="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span style="outline: 0px;visibility: visible;font-size: 15px;background-color: rgb(255, 255, 255);">替尔泊肽</span></strong><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（Tirzepatide）</span><span arial="" gb="" helvetica="" neue="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">是一种葡萄糖依赖性促胰岛素多肽</span><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（GIP）</span><span arial="" gb="" helvetica="" neue="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">受体和胰高血糖素样肽-1</span><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（GLP-1）</span><span arial="" gb="" helvetica="" neue="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">受体的双重作用激动剂。激活GLP-1受体，能够减少饥饿感，从而减少饮食和热量摄入，而激活GIP受体可以减少饮食和热量摄入并增加能量消耗。二者结合，可对体重、葡萄糖和脂质等代谢失调标志物产生更大影响。</span></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span arial="" gb="" helvetica="" neue="" normal="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><br/></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span arial="" gb="" helvetica="" neue="" normal="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><img class="rich_pages wxw-img" data-backh="325" data-backw="578" data-galleryid="" data-ratio="0.5611111111111111" data-s="300,640" data-src="https://mmbiz.qpic.cn/mmbiz_png/HO0Z9pUcnJllUdjUgrbaL5nj59Ox0NJok20wOybcIyfNXdjrkxhRN4vj6nD0CYoqCJibFaKIQEO4WpcYgBM7IdQ/640?wx_fmt=png" data-type="png" data-w="1080" style="letter-spacing: 0.578px;text-align: center;white-space: normal;box-shadow: rgb(210, 210, 210) 0em 0em 0.5em 0px;width: 100%;height: auto;"/></span></section><section arial="" center="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">作为降糖药的替尔泊肽（Tirzepatide）</span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span arial="" gb="" helvetica="" neue="" normal="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><br/></span></section><section arial="" center="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="color: rgb(2, 30, 170);"><strong><span arial="" gb="" helvetica="" neue="" normal="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">对非糖尿病患者的减肥效果</span></strong></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span arial="" gb="" helvetica="" neue="" normal="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><br/></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="outline: 0px;font-size: 15px;letter-spacing: normal;">在2022年4月28日公布的<span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">SURMOUNT-1研究中，<span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">共招募了2539名超重或肥胖的成年人参与，他们平均体重为105公斤，且没有患糖尿病。每周一次皮下注射</span><strong arial="" gb="" helvetica="" neue="" normal="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span style="outline: 0px;font-size: 15px;">替尔泊肽</span></strong><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（Tirzepatide）</span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">治疗，治疗剂量分别为5mg、10mg、15mg。所有治疗参与者均从2.5mg剂量开始，然后每四周增加2.5mg剂量，各组分别达到<span style="outline: 0px;">5mg、10mg、15mg剂量后维持。</span></span></span></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="outline: 0px;font-size: 15px;letter-spacing: normal;"><br/></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="color: rgb(34, 34, 34);outline: 0px;font-size: 15px;letter-spacing: normal;">经过为期72周的</span><strong style="color: rgb(34, 34, 34);letter-spacing: 0.544px;"><span style="outline: 0px;font-size: 15px;letter-spacing: normal;">替尔泊肽</span></strong><span style="color: rgb(136, 136, 136);font-size: 15px;letter-spacing: normal;outline: 0px;visibility: visible;">（Tirzepatide）</span><span style="color: rgb(34, 34, 34);outline: 0px;font-size: 15px;letter-spacing: normal;">治疗，15mg剂量组的</span><span style="color: rgb(34, 34, 34);font-size: 15px;letter-spacing: normal;">参与者平均体重减轻高达22.5%</span><span style="color: rgb(136, 136, 136);font-size: 15px;letter-spacing: normal;">（24公斤）</span><span style="color: rgb(34, 34, 34);font-size: 15px;letter-spacing: normal;">。</span><span style="font-size: 15px;letter-spacing: normal;color: rgb(34, 34, 34);">礼来公司表示，</span><span style="outline: 0px;font-size: 15px;letter-spacing: normal;color: rgb(217, 33, 66);">这是首个在3期临床试验中平均减重效果超过20%的研究性药物</span><span style="color: rgb(34, 34, 34);outline: 0px;font-size: 15px;letter-spacing: normal;">，这一临床数据增强了该药物对治疗肥胖症的信心。</span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><br/></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="color: rgb(34, 34, 34);outline: 0px;font-size: 15px;letter-spacing: normal;">对于安全性和耐受性，<strong arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span style="outline: 0px;font-size: 15px;">替尔泊肽</span></strong><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（Tirzepatide）</span>治疗的副作用与其他治疗肥胖症的基于肠促胰岛素的疗法相似，最常见的副作用与胃肠道有关，副作用多为轻度至中度，通常发生在剂量递增期间。</span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="color: rgb(34, 34, 34);outline: 0px;font-size: 15px;letter-spacing: normal;"><br/></span></section><section arial="" center="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="color: rgb(34, 34, 34);outline: 0px;font-size: 15px;letter-spacing: normal;"><strong arial="" center="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(2, 30, 170);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span style="outline: 0px;font-size: 15px;visibility: visible;">对糖尿病患者的减肥效果</span></strong></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="color: rgb(34, 34, 34);outline: 0px;font-size: 15px;letter-spacing: normal;"><strong arial="" center="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(2, 30, 170);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span style="outline: 0px;font-size: 15px;visibility: visible;"><br/></span></strong></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="color: rgb(34, 34, 34);outline: 0px;font-size: 15px;letter-spacing: normal;">在此次公布的</span><span style="color: rgb(34, 34, 34);font-size: 15px;letter-spacing: normal;">SURMOUNT-2研究中</span><span style="color: rgb(34, 34, 34);outline: 0px;font-size: 15px;letter-spacing: normal;">，共招募了<span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">938名</span>患有糖尿病的肥胖或超重患者参与，他们平均体重<span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">100.7公斤，在经过72周治疗后，10mg剂量组<span arial="" gb="" helvetica="" neue="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">的</span><span arial="" gb="" helvetica="" neue="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">参与者平均体重减</span></span>轻13.4%</span><span style="outline: 0px;font-size: 15px;letter-spacing: normal;color: rgb(136, 136, 136);">（13.5kg）</span><span style="color: rgb(34, 34, 34);outline: 0px;font-size: 15px;letter-spacing: normal;">，<strong>15mg剂量组<span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span style="background-color: rgb(255, 255, 255);">平均体重减</span>轻</span><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">15.7%</span></strong></span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">（15.6kg）</span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">。而<span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">接受安慰剂治疗的患者体重平均减轻3.3%</span></span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">。</span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><br/></section><section arial="" center="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><strong><span style="font-size: 15px;letter-spacing: normal;color: rgb(2, 30, 170);">减肥效果全面优于司美格鲁肽？</span></strong></section><section arial="" center="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><br/></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="color: rgb(34, 34, 34);font-size: 15px;letter-spacing: normal;">从上述两项3期临床试验结果来看，<strong arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span style="outline: 0px;font-size: 15px;">替尔泊肽</span></strong><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（Tirzepatide）</span>无论是在糖尿病患者还是在非糖尿病患者中减肥效果都要优于其竞争对手</span><strong><span style="color: rgb(34, 34, 34);font-size: 15px;letter-spacing: normal;">司美格鲁肽</span></strong><span style="color:#222222;"><span style="font-size: 15px;letter-spacing: normal;color: rgb(136, 136, 136);">（Semaglutide）</span><span style="font-size: 15px;letter-spacing: normal;">。</span></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="color: rgb(34, 34, 34);font-size: 15px;letter-spacing: normal;"><br/></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="color: rgb(34, 34, 34);font-size: 15px;letter-spacing: normal;">在肥胖或超重的糖尿病患者中，<span style="color: rgb(34, 34, 34);font-size: 15px;">司美格鲁肽</span><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">（Semaglutide）</span>在68周的治疗后，平均减重效果为9.6%，而<span style="outline: 0px;">替尔泊肽</span><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（Tirzepatide）</span>则为15.7%。在非糖尿病的肥胖患者中，司美格鲁肽<span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">（Semaglutide）</span>平均减重效果为15%，而<span arial="" gb="" helvetica="" neue="" normal="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span style="outline: 0px;">替尔泊肽</span><span style="background-color: rgb(255, 255, 255);color: rgb(136, 136, 136);outline: 0px;visibility: visible;">（Tirzepatide）</span>则为22.5%。</span></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span arial="" gb="" helvetica="" neue="" normal="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei=""><br/></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="color: rgb(34, 34, 34);font-size: 15px;letter-spacing: normal;"><span arial="" gb="" helvetica="" neue="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">为了更好地验证<strong arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span style="outline: 0px;">替尔泊肽</span></strong><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（Tirzepatide）</span></span>与</span><strong><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">司美格鲁肽</span></strong><span style="color: rgb(34, 34, 34);font-size: 15px;letter-spacing: normal;"><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;visibility: visible;font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">（Semaglutide）</span>的减肥效果，礼来公司于上周开启了一项新的3期临床试验——<span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">SURMOUNT-5</span>，这项临床试验</span><span style="font-size: 15px;letter-spacing: normal;color: rgb(34, 34, 34);">旨在评估这两种减肥药物用于成人肥胖或超重且伴有体重相关合并症的非糖尿病患者的有效性与安全性。这也是<span style="outline: 0px;">替尔泊肽</span><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（Tirzepatide）</span>减重适应症首次头对头<span style="color: rgb(34, 34, 34);font-size: 15px;">司美格鲁肽</span><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（Semaglutide）</span>的临床研究。</span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="font-size: 15px;letter-spacing: normal;color: rgb(34, 34, 34);"><br/></span></section><section arial="" center="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="font-size: 15px;letter-spacing: normal;color: rgb(2, 30, 170);"><strong arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span style="font-size: 15px;color: rgb(2, 30, 170);outline: 0px;">或在五年内成为减肥药销售之王</span></strong></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><br/></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="font-size: 15px;letter-spacing: normal;color: rgb(34, 34, 34);">根据诺和诺德公布的2022年财报，其2022年的总销售额为249.94亿美元，其中<span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">司美格鲁肽</span><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（Semaglutide）</span>高达109亿美元，成为首款销售额超过100亿美元的GLP-1受体激动剂。</span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="font-size: 15px;letter-spacing: normal;color: rgb(34, 34, 34);"><br/></span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><span style="font-size: 15px;letter-spacing: normal;color: rgb(34, 34, 34);">基于<strong><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">替尔泊肽</span></strong><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（Tirzepatide）</span>的SURMOUNT-1临床试验结果，华尔街投资银行 <strong>Cowen</strong> 的分析师认为，<span style="outline: 0px;">替尔泊肽</span><span arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（Tirzepatide）</span>将成为潜在的“</span><span style="font-size: 15px;letter-spacing: normal;color: rgb(217, 33, 66);">首选减肥药</span><span style="font-size: 15px;letter-spacing: normal;color: rgb(34, 34, 34);">”，来自</span><span style="color: rgb(34, 34, 34);font-size: 15px;letter-spacing: normal;">专家顾问和医生的反馈表明，</span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="color: rgb(217, 33, 66);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">替尔泊肽</span><span arial="" gb="" helvetica="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei="">（Tirzepatide）</span><span style="font-size: 15px;letter-spacing: normal;color: rgb(217, 33, 66);">很可能在五年内成为销售额最高的减肥药。</span></section><section arial="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;outline: 0px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, " ui="" visible="" yahei=""><br/></section><section arial="" gb="" helvetica="" left="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span style="outline: 0px;letter-spacing: normal;"><strong style="outline: 0px;"><span arial="" gb="" helvetica="" neue="" sans="" sans-serif="" sc="" style="outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">参考资料</span></strong><span arial="" gb="" helvetica="" neue="" sans="" sans-serif="" sc="" style="outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">：<br style="outline: 0px;"/></span></span></section><section arial="" gb="" helvetica="" left="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span arial="" gb="" helvetica="" neue="" normal="" sans="" sans-serif="" sc="" style="outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">1. https://www.prnewswire.com/news-releases/lillys-tirzepatide-delivered-up-to-22-5-weight-loss-in-adults-with-obesity-or-overweight-in-surmount-1--301534871.html</span></section><section arial="" gb="" helvetica="" left="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span arial="" gb="" helvetica="" neue="" normal="" sans="" sans-serif="" sc="" style="outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">2. https://www.fiercepharma.com/pharma/eli-lillys-tirzepatide-passes-2nd-obesity-weight-loss-trial-gunning-fda-nod-2023</span></section><section arial="" gb="" helvetica="" left="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span arial="" gb="" helvetica="" neue="" normal="" sans="" sans-serif="" sc="" style="outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span style="color: rgb(136, 136, 136);font-family: PingFangSC-Regular;font-size: 12px;letter-spacing: normal;text-align: start;white-space: pre-wrap;caret-color: rgb(42, 43, 46);background-color: rgb(255, 255, 255);">3. https://doi.org/10.1016/j.cmet.2023.02.003</span></span></section><section arial="" gb="" helvetica="" left="" neue="" normal="" rgb="" sans="" sans-serif="" sc="" style="outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span arial="" gb="" helvetica="" neue="" normal="" sans="" sans-serif="" sc="" style="outline: 0px;color: rgb(136, 136, 136);font-family: -apple-system, BlinkMacSystemFont, " ui="" yahei="">4. https://www.nejm.org/doi/full/10.1056/NEJMoa2032183?query=featured_home</span></section><section arial="" gb="" helvetica="" neue="" rgb="" right="" sans="" sans-serif="" sc="" style="margin-top: 16px;margin-bottom: 0px;font-size: 16px;white-space: normal;outline: 0px;color: rgb(3, 110, 183);font-family: system-ui, -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span style="outline: 0px;color: rgb(149, 151, 153);font-size: 12px;letter-spacing: 0.5px;">封面图来源：网络</span></section><section arial="" center="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 16px;font-size: 16px;white-space: normal;outline: 0px;color: rgb(3, 110, 183);font-family: system-ui, -apple-system, BlinkMacSystemFont, " ui="" yahei=""><img class="rich_pages wxw-img" data-backh="19" data-backw="558" data-ratio="0.03333333333333333" data-src="https://mmbiz.qpic.cn/mmbiz_png/Lkw2iaE07M9VdpWTCkMvY4ibwPdadaqz8TiaC6QUHo2ay416OJfe0eCs0bgZ74JoSIoCm8qJDHeicdictolYDRhandw/640?wx_fmt=png&wxfrom=5&wx_lazy=1&wx_co=1" data-w="1080" style="outline: 0px;width: 100%;visibility: visible !important;height: auto;"/></section><p arial="" center="" gb="" helvetica="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-bottom: 0px;font-size: 16px;white-space: normal;outline: 0px;color: rgb(3, 110, 183);font-family: system-ui, -apple-system, BlinkMacSystemFont, " ui="" yahei=""><img class="rich_pages wxw-img" data-backh="314" data-backw="558" data-ratio="0.562962962962963" data-src="https://mmbiz.qpic.cn/mmbiz_png/Lkw2iaE07M9VFxaFRQVoia9s9fTTNz0CfUd5MebHzhxLic1ic7D33R3pYPGeohRciateHfq4XCia7WNiaVYabPmeUiaEfQ/640?wx_fmt=png&wxfrom=5&wx_lazy=1&wx_co=1" data-w="1080" style="outline: 0px;width: 100%;visibility: visible !important;height: auto;"/></p><section arial="" gb="" helvetica="" left="" neue="" rgb="" sans="" sans-serif="" sc="" style="margin-top: 8px;margin-bottom: 0px;font-size: 16px;white-space: normal;outline: 0px;color: rgb(3, 110, 183);font-family: system-ui, -apple-system, BlinkMacSystemFont, " ui="" yahei=""><span bold="" pingfang="" sc="" style="outline: 0px;letter-spacing: 0.544px;color: rgb(232, 22, 105);font-family: PingFangSC-Medium, "><img class="rich_pages wxw-img __bg_gif" data-ratio="0.5982532751091703" data-src="https://mmbiz.qpic.cn/mmbiz_gif/MfTd6rd9CyvNRMW8I9cvI1CK5gKiaYqg2veTn9t9dAe1GxYic7pAvgvRIKNFickConFyX8AvW2reAq8GchJI6aBpA/640?wx_fmt=gif&wxfrom=5&wx_lazy=1" data-w="458" data-width="100%" style="vertical-align: middle;letter-spacing: 0.544px;outline: 0px;caret-color: rgba(0, 0, 0, 0);text-align: center;color: rgb(62, 62, 62);visibility: visible !important;width: 56.5938px !important;"/>点击报名</span><span bold="" pingfang="" sc="" style="padding-right: 5px;padding-left: 5px;outline: 0px;letter-spacing: 0.544px;color: rgb(232, 22, 105);font-family: PingFangSC-Medium, ">，学无止境，闪药人生！</span></section><p style="display: none;margin-bottom: 24px;"><mp-style-type data-value="10000"/></p></div>